太阳成集团tyc9728-太阳集团见好就收9728

Location： Home» Faculty» Faculty

Faculty

Yang Zhen

Professor

email: zyang@pku.edu.cn

Tel: 86-10-6275-9105

Fax: 86-10-6275-9105

Group website: /zliu/

Academic Education and Professional Experience:

Ph. D. In Chemistry The Chinese University of Hong Kong (1989 – 1992)
M.S. in Medicinal Chemistry Shenyang College of Pharmacy, P. R. China (1983-1986)
B.S. in Medicinal Chemistry Shenyang College of Pharmacy, P. R. China (1978-1982)
Feng Xinde Polymer Prize by “Polymer” (Elsevier, 2010)
National Science Fund for Distinguished Young Scholars of China (2012)
2001.9-present Changjiang Professor
College of Chemistry, Peking University, Beijing, China
Research Interest:
Total Synthesis of Natural Product and Organometallic Chemistry
Diversity Oriented Synthesis and Chemical Biology
2005.9-present Director of Chemistry
XTL Biophamaceutical, New York, USA
Research Interest:
Medicinal Chemistry and Combinatorial Chemistry
2001.5-2005,9 Co-Founder and Director of Chemistry
VivoQuest. Inc. New York, USA
Research Interest:
Anti-Viral Drug Discovery
1998.5-2001.5 Institute fellow
Harvard Institute of Chemistry and Cell Biology,
Harvard University
Research Interest: Diversity Oriented Synthesis
1995.6-1998.5 Assistant Professor
The Scripps Research Institute
Research Interest: Total Synthesis of Complex Natural Products
1992.5-1995.5 Postdoctoral Fellow
The Scripps Research Institute
Topic: Total Syntheses of Taxol, Brevetoxin A and Epothilone A

Honor:

2000’s Young Investigator Award (abroad), NSF of China
2001’s Glaxo-Simth-Kline Drug Discovery and Development Award (USA)
2004’s Young Investigator Award, NSF of China
2005 Eli Lilly Scientific Excellence Award (China)
Research Interests: Development of synthetic methods for the synthesis of complex natural product molecules and application of synthetic chemistry for drug discovery

Select publications:

Yang, Z.; Hon, P.-M.; Chui, K.-Y.; Xu, Z.-L.; Chang, H.-M.; Lee, C.-M.; Cui, Y.-X.; Wong, H.N.C.; Poon, C.-D.; Fung, B.-M. “(3-Hydroxypropyl)-7-methoxy-2-(3’-methoxy-4’-hydroxyphenyl)-3-benzo[b]furancarbaldehyde, a novel adenosine A1 receptor ligand, isolated from Salvia miltiorrhiza Bunge (Danshen).” Tetrahedron lett.. 1991, 32, 2061-2064.
Yang, Z.; Cui, Y.-X.; Wong, H.N.C.; Wang, R.-J.; Mark, T.C.W.; Chang, H.-M.; and Lee, C.-M.;. “Anodic oxidation as a synthetic expedient to naphthoquinone and anthraquinone ketals.” Tetrahedron 1992, 48, 3293-3302.
Yang, Z.; Wong, H.N.C.; Hon, B.-M.; Chang, H.-M.; Lee, C.-M.; “A novel synthesis of the dibenzo[b,f]oxepin ring system: 10,11-dihydro-11-hydroxydibenzo[b,f]oxepin-10(11H)-one.” J. Org. Chem. 1992, 57, 4033-4034.
Wong, H.N.C.; Niu, C.-R.; Yang, Z.; Hon, B.-M.; Chang, H.-M.; Lee, C.-M.; “Regiospecific introduction of carbon-3 formal group to 2,5-dialkyl-7-methoxy-benzo[b]furans: synthesis of potential ligand for adenosine A1 receptor.” Tetrahedron 1992, 48, 10339-10344.
Yang, Z.; Liu, H.-B.; Lee, C.-M.; Chang, H.-M.; Wong, H.N.C.; Regioselective introduction of carbon-3 substitutes to 5-alkyl-7-methoxy-2-phenylbenzo[b]furans: synthesis of a novel adenosine A1 receptor ligand and its derivatives.” J. Org. Chem. 1992, 57, 7248-7252.
Nicolaou, K.C.; Yang, Z.; Sorensen, E.J.; Nakada, M. “Synthesis of ABC taxoid ring system via a convergent strategy.” J. Chem. Soc., Chem. Commun. 1993, 1024-1026.
Nicolaou, K.C.; Yang, Z.; Liu, J.-J.; Ueno, H.; Nantermet, P.G.; Guy, R.K.; Claiborne, C.F.; Renaud, J.; Couladouros, E.A.; Paulvannan, K.; Sorensen, E.J. “Total synthesis of Taxol.” Nature, 1994, 367, 630-634.
Nicolaou, K.C.; Yue, E.W.; Naniwa, Y.; Riccardis, F.D.; Nadin, A.; Leresche, J.E.; Greca, S.L.; Yang, Z. “Zaragozic Acid/Squalestatin S1: Synthetic and Retrosynthetic Studies.” Angew. Chem. Int. Ed. Engl. 1994, 33, 2184-2187.
Nicolaou, K.C.; Nadin, A.; Leresche, J.E.; Greca, S.L.; Tsuri, T.; Yue, E.W.; Yang, Z. “Synthesis of the first fully functionalized core of the zaragozic acid/squalestatins.” Angew. Chem. Int. Ed. Engl. 1994, 33, 2187-2191.
Nicolaou, K.C.; Liu, J. J.; Yang, Z.; Nantermet, P.G.; Claiborne, C.F.; Renaud, J.; Guy, R.K.; Shibayama, K “Construction of A and C ring intermediates and initial attempts to construct the ABC ring system.” J. Am. Chem. Soc. 1995, 117, 634-644.
Nicolaou, K.C.; Yang, Z.; Liu, J. J.; Nantermet, P.G.; Claiborne, C.F.; Renaud, J.; Guy, R.K.; Shibayama, K. “Total synthesis of taxol. 3. Formation of taxol’s ABC ring skeleton.” J. Am. Chem. Soc. 1995, 117, 645-652.
Nicolaou, K.C.; Ueno, H.; Liu, J. J.; Nantermet, P.G.; Yang, Z.; Renaud, J.; Paulvannan, K.; Chadha, R. “Total synthesis of taxol. 4. The final stages and completion of the synthesis.” J. Am. Chem. Soc. 1995, 117, 653-659.
Nicolaou, K.C.; Yue, E.W.; Greca, S.L.; Nadin, A.; Yang, Z.; Leresche, J.E.; Tsuri,G.T.;
Naniwa, Y..; Riccardis, F. D. “Synthesis of zaragozic acid A/squalestatin S1.” Chem. Eur. J. 1995, 1, 467-494.
Johnson, C. R.; Xu, Y-P.; Nicolaou, K. C.; Yang, Z.; Guy, R. K.; Dong, J.-G.; Berova, N. “Enzymatic resolution of a key stereochemical intermediate for the synthesis of taxol.”Tetrahedron Lett. 1995, 36, 3291-3294.
Nicolaou, K.C.; Theodorakis, E.A.; Rutjies, F.P.J.T.; Sato, M.; Tiebes, J.; Xiao, X.-Y.; Hwang, C.-K.; Duggan, M. E.; Yang, Z.; Couladouros, E.A.; Sato, F.; Shin, J.; He, H.-M.; Bleckman, T. “Total synthesis of brevetoxin B. 2. Second generation strategies and construction of the dioxepane region [DEFG].” J. Am. Chem. Soc. 1995, 117, 10239-0251.
Nicolaou, K.C.; He, Y.; Vourloumis, D.; Vallberg, H; Yang, Z. “An approach to epothilones based on olefin metathesis.” Angew. Chem. Int. Ed. Engl. 1996, 35, 2399-2401.
Yang, Z.; He, Y.; Vourloumis, D.; Vallberg, H.; Nicolaou, K.C. “Total Synthesis of Epothilone A: The Olefin Metathesis Approach” Angew. Chem. Int. Ed. Engl. 1997, 36, 166-168.
Nicolaou, K.C; Sarabia, F.; Ninkovic, S.; Yang, Z. “Total synthesis of epothilone A: the marcrolactonization approach.” Angw. Chem. Int. Ed. Engl. 1997, 36, 525-527.
Nicolaou, K.C.; Winssinger, N.; Pastor, J.; Ninkvic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E. “Synthesis of epothilones A and B in solid and solution phase.” Nature 1997, 387, 268-272.
Nicolaou, K.C.; Yang, Z.; Quellette, M.; Shi, G.-Q.; Gartner, P.; Gunzner, J.L.; Agrios, C.; Huber, R.; Chadha, R.; Huang, D.H. “New synthetic technology for the construction of 9-membered ring cyclic ethers. Construction of the EFGH ring skeleton of brevetoxin A.” J. Am. Chem. Soc. 1997, 119, 8105-8106.
Nicolaou, K.C.; Shi, G.-Q.; Gunzner, J.L.; Gartner, P.; Yang, Z. “Palladium-catalyzed functionalization of lactones via their cyclic ketene acetal phosphates. Efficient new synthetic technology for the construction of medium and large cyclic ether” J. Am. Chem. Soc. 1997, 119, 5467-5468.
Nicolaou, K.C.; He, Y.; Vourloumis, D.; Vallberg, H.; Roschangar, F.; Sarabia, F.; Ninkovic, S.; Yang, Z. “The olefin metathesis approach to epothilone A and its analogs” J. Am. Chem. Soc, 1997, 119, 7960-7973.
Nicolaou, K.C.; Ninkovic, S.; Sarabia, F.; Vourloumis, D.; He, Y.; Vallberg, H.; Yang, Z. “Total synthesis of epotheliones A and B via a macrolactonization based stratagy. J. Am. Chem. Soc. 1997, 119, 7974-7991.
Nicolaou, K. C.; Yang, Z.; Shi, G.-Q.; Gunzner, J. L.; Agrios, K. A.; Garttner, P. “Total synthesis of Brevetoxin A” Nature 1998, 392, 264-269.
McAlpine, S. R.; Schreiber, S. L.; Sorger, P.; Copeland, J; Yang, Z. “Comparison of four solid support resins using optical analysis, and analysis of their release in aqueous media. a condensation library investigates the advantages of each solid support.” Book of Abstracts, 217th ACS National Meeting, Anaheim, Calif., March 21-25 (1999), ORGN-170. Publisher: American Chemical Society, Washington, D. C. CODEN: 67GHA6. AN 1999:145603 CAPLUS.
Nicolaou, K. C.; Gunzner, J. L.; Shi, G.-Q.; Agrios, K. A.; Gartner, P.; Yang, Z. “Total synthesis of brevetoxin A: Part 4: final stages and completion” Chem. Eur. J. 1999, 5(2), 646-658.
Nicolaou, K. C.; Shi, G. Q.; Gunzner, J. L.; Gartner, P.; Wallace, P. A.; Ouellette, M. A.; Shi, S.-H.; Bunnage, M. E.; Agrios, K. A.; Veale, C. A.; Hwang, C.-K.; Hutchinson, J.; Prasad, C. V. C.; Ogilvie, W. W.; Yang, Z. “Total synthesis of brevetoxin A: Part 3: construction of GHIJ and BCDE ring systems” Chem. Eur. J. 1999, 5(2), 628-645.
Nicolaou, K. C.; Wallace, P. A.; Shi, S. H.; Ouellette, M. A.; Bunnage, M. E.; Gunzner, J. L.; Agrios, K. A.; Shi, G. Q.; Gartner, P.; Yang, Z. “Total synthesis of brevetoxin A: Part 2: second generation strategy and construction of EFGH model system” Chem. Eur. J. 1999, 5(2), 618-627.
Nicolaou, K. C.; Bunnage, M. E.; McGarry, D. G.; Shi, S. H.; Somers, P. K.; Wallace, Paul A.; Chu, X. J.; Agrios, K. A.; Gunzner, J. L.; Yang, Z. “Total synthesis of brevetoxin A: Part 1: first generation strategy and construction of BCD ring system” Chem. Eur. J. 1999, 5(2), 599-617.
Nan, Y.; Yang, Z. “Nickel-Catalyzed Cross-Coupling of Cyclohexenyl Phosphate and Arylboronic Acids” Tetrahedron Lett. 1999,40, 3321-3324.
Nan, Y.; Miao, H.; Yang, Z. “A new complex of palladium-thiourea and carbon tetrabromide catalyzed carbonylative annulation of hydroxy-phenylacetylenes; Efficient new synthetic technology for the synthesis of 2,3-disubtituted benzo[b]furans” Org. Lett. 2000, 2, 297.
Maio, H.; Yang, Z. “ Regio-specific carbonylative annulation of iodophenol acetates and acetylenes to construct the flavones by a new catalyst of palladiu-thiourea-dppp complex.” Org. Lett. 2000, 2, 1765-1768.
Hu, Y.-H.; Zhang, Y.; Fathi, R.; and Yang, Z. “Palladium-catalyzed Carbonylative Annulation of o-Alkynylphenols: Syntheses of 2-Substituted-3-aroyl-benzo[b]furans.” J. Org. Chem. 2002, 67, 2365-2368.
Liao, Y.; Fathi, R.; Reitman, M.; Zhang, Y.; Yang, Z. “Optimisation study of Sonogashira Cross-Coupling Reaction on High-Loading Macrobeads Using a Silyl Linker Systematic Study of Sonogashira Cross-Coupling Reaction on the High-Loading Macrobeads Using a Silyl Linker.” Tetrahedron Lett. 2001, 42, 1815-1818.
Hu, Y.-H.; Yang, Z. “The Palladium-Mediated Intramolecular Carbonylative Annulation of o-Alkynylphenols to Synthesisze Beozo[b]furo[3,4-d]furan-1-ones” Org. Lett. 2001, 3, 1387-1390.
Wu, J.; Liao, Y.; Yang, Z “The Synthesis of 4-Substituted Coumarins via the Palladium-catalyzed Cross-couplings of 4-Tosyl-coumarins with Terminal Acetylenes and Organozinc Reagents”. J. Org. Chem. 2001, 66, 3642-3645.
Wu, J.; Yang, Z. “The Nickel-Catalyzed Cross-Couplings of 4-Diethylphosphono-oxycoumarins with Organozinc Reagents: An Efficient New Methodology for the Synthesis of 4-Substituted Coumarins” J. Org. Chem. 2001, 66, 7875-7878.
Hu, Y.-H.; Zhang, Y.; Yang, Z.; Fathi, R. “Palladium-catalyzed Carbonylative Annulation of o-Alkynylphenols: Synthesis of 2-Substituted-3-aroyl-benzo[b]furans” J. Org. Chem. 2002, 67, 2365-2368.
Wu, J.; Wang, L.; Fathi, R.; Yang, Z. “Palladium-catalyzed cross-coupling reactions of 4-tosylcoumarin and arylboronic acids: synthesis of 4-arylcoumarin compounds” Tetrahedron Lett. 2002, 43, 4395-4398.
Yun. L.; Reitman, M.; Zhang, Y.; Fathi, R.; Yang, Z. “Palladium(II)-mediated cascade carbonylative annulation of o-alkylnylphenols on a silyl linker based macrobeads: a combinatorial synthesis of a 2-substituted-benzo[b]furan-3-carboxylate library” Org. Lett. 2002, 4, 2607-2609.
Zhu, Q.; Wu, J.; Fathi, R.; Yang, Z. “The First Observation of Phenyliodonium Zwitterion as Efficient Electrophile in the Palladium Catalyzed Suzuki-type Reaction: a Novel Method for the Synthesis of 3-Aryl-4-hydroxyl-coumarins” Org. Lett. 2002, 4, 3333-3336.
Liao, Y.; Fathi, R.; Yang. Z. “Convergent solid-phase synthesis of symmetrical benzo[b]furan’s dimerizer” J. Comb. Chem. 2003, 5, 79-81.
Wu, J.; Zhu, Q.; Wang, L.; Fathi, R.; Yang, Z. “Palladium-Catalyzed Cross-Coupling Reactions of 4-Tosyl-2(5H)-furanone with Boronic Acids: A Facile and Efficient Route to Generate 4-Substituted 2(5H)-Furanones” J. Org. Chem. 2003, 68, 670 - 673.
Liao, Y.; Fathi, R.; Yang. Z. “A Highly-Efficient Aliphatic Acetylenic Homocoupling Catalyzed by a Novel Combination of AgOTs-CuCl2-TMEDA and Its Application for the Solid Phase Synthesis of bis-Benzo[b]furan-linked 1,3-Diynes” Org. Lett. 2003, 5, 909-912.
Mao S. Cheng, M. S.; Wang, Q. L.; Tian, Q.; Song, H. Y.; Liu, Y. X.; Li, Q.; Xu, X.; Miao, H. D.; Yao, X. S.; Yang, Z. “Total Synthesis of Methyl Protodioscin: A Potent Agent with Anti-tumor Activity” J. Org. Chem. 2003, 68, 3658-3662.
Liao, Y.; Hu, Y.-H.; Wu, J.; Zhu, Q.; Donovan, M.; Fathi, R.; Yang, Z. “Diversity Oriented Synthesis and Branching Reaction Pathway to Generate Natural Product-like Compounds” Curr. Med. Chem. 2003, 10, 2285-2316.
Li, C.-C.; Xie, Z.-S.; Zhang, Y.-D.; Yang, Z “Total Synthesis of Wedelolactone”. J. Org. Chem. 2003, 68, 8500-8506.
Dai, M.-J.; Wang, C.-H.; Xiang, J.; Liang, B.; Luo, T.-P.; Chen, J.-H.; Yang, Z. “Development of Thiourea-based Ligands for the Palladium-catalyzed Bismethoxycarbonylation of Terminal Olefins” Eur. J. Org. Chem. 2003, 4346-4348.
Kobori, M.; Yang, Z.; Heissmeyer, V.; Zhu, H.; Jung, Y-K.; Gakidis, M. A. M.; Rao, A.; Sekine, T.; Ikegami, F.; Yuan, C.; Yuan, J. “Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex” Cell Death and Differentiation 2003,
Dai, M.; Liang B.; Wang, C.; Chen, J.; Yang, Z. “Synthesis of a Novel C2-Symmetric Thiourea and Its Application in the Pd-Catalyzed Cross-Coupling Reactions with Arenediazonium Salts under Aerobic Conditions” Org. Lett. 2004, 6, 221-224.
Xiang, Z.; Luo, T.; Lu, K.; Cui, J.; Shi, X.; Fathi, R. Chen. J.; Yang Z. “Concise Syntheisis of Isoquinoline via the Ugi and Heck Reactions“Org Lett. 2004, 6, 3155-3158.
Xiong, Z.; Wang, N.; Dai, M.; Li, A.; Chen, J.; Yang, Z. “Synthesis of Novel Palladacycles and Their Application in Heck and Suzuki Reactions under Aerobic Conditions” Org. Lett. 2004, 6, 3337-3340.
Dai, M.; Liang, B.; Wang, C.; You, Z.; Xiang, J.; Dong, G.; Chen, J. Yang, Z. “A Novel Thiourea Ligand Applied in the Pd-Catalyzed Heck, Suzuki, Suzuki Carbonylative Reactions” Adv, Synth. Catal. 2004, 346, 1669-1673.
Liang, B.; Dai, M.; Chen, J.; Yang, Z.“ Copper-Free Sonogashira Coupling Reaction with PdCl2 in Water under Aerobic Conditions” J. Org. Chem. 2005, 70, 391-393.
Tang, Y.; Deng, L.; Zhang, Y.; Dong, G.; Chen, J.; Yang, Z. “Tetramethyl Thiourea/Co2(CO)8-Catalyzed Pauson-Khand Reaction under Balloon Pressure of CO” Org. Lett. 2005, 7, 593-595.
Tang, Y.; Zhang, Y.; Dai, M.; Luo, T.; Deng, L.; Chen, J.; Yang, Z. “A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of Thioureas as Ligands in the Co-catalyzed Pauson-Khand Reaction and Pd-Catalyzed Carbonylative Annulation” Org. Lett. 2005, 7, 885-888.
Li. C.; Liang, S.; Zhang, X.; Xie, Z.; Chen, J.; Wu, Y.; Yang. “Eploring an Expedient IMDA Reaction Approach to Construct the Guanacastepene Core“ Org. Lett. 2005, 7, 3709.
Liang, B.; Huang, M.; You, Z.; Xiong, Z.; Lu, K.; Fathi, R.; Chen, J. ; Yang, Z. “Pd-Catalyzed Copper-Free Carbonylative Sonogashira Reaction of Aryl Iodides with Alkynes for the Synthesis of Alkynyl Ketones and Flavones by Using Water as a Solvent” J. Org. Chem. 2005, 70, 6097.
Tang, Y.; Deng, L.; Zhang, Y.; Dong, G.; Chen, J.; Yang, Z. “Thioureas as Ligands in the Pd-Catalyzed Intramolecular Pauson-Khand Reaction” Org. Lett. 2005, 7, 1657.
Liao, Y.; Smith, J.; Fathi, R.; Yang, Z. Org. Lett. 2005, 7, 2707-2709.
Wang, C.; Hu, R.; Liang, S.; Chen. J.; Yang, Z.; Pei, J. “Linear C2-symmetric polycyclic benzodithiophene: efficient, highly diversified approaches and the optical properties“ Tetrahedron Lett. 2005, 46, 8153.
Lu, K.; Luo, T.; Xiang, Z.; You, Z.; Fathi, R.; Chen, J.; Yang, Z. “A Concise and Diversity-Oriented Strategy for the Synhteis of Benzofurans and Indoles via Ugi and Dields- Alder Reaction” J. Comb. Chem. 2005, 7, 958.
Zhang, Y.; Tang, Y.; Luo, T.; Shen, J.; Chen, J.; Yang, Z. “Application of RCM Reaction in the Construction of ABC Ring of Micrandilactone A” Org. Lett. 2006, 8, 2006.
Lu, K.; Huang, M.; Xiang, Z.; Liu, Y.; Chen, J.; Yang. Z. “Development of a Concise and Diversity-Oriented Approach for the Synthesis of Plecomacrolides via the Diene-Ene RCM” Org. Lett. 2006, 8, 1193.
Ma, Z.; Xiang, Z.; Luo, T.; Lu, K.; Xu, Z.; Chen, J. Yang, Z. “Synthesis of Functionalized Quinolines via Ugi and Pd-Catalyzed Intramolecular Arylation Reactions” J. Comb. Chen. 2006, in press.
Li, C. ; Wang, C. ; Liang, B. ; Zhang, X. ; Deng, L. ; Liang, S. ; Chen, J. ; Wu, Y. ; Yang, Z. “ Synthetic Study of 1,3-Butadiene-Based IMDA Approach to Construct a [5-7-6] Tricyclic Core and Its Application to the Total Synthesis of C8-epi-Guanacastepene O” J. Org. Chem. 2006, 71, 6892.
Wu, X.; Zhong, H.; Song, J.; Damoiseaux, R. ; Yang, Z. ; Lin S. ”Mycophenolic Acid is a Potent Inhibitor of Angiogenesis” Arterioscler Thromb Vasc Biol. 2006, 26, 2414-6.
Liu, Y.; Lu, K.; Dai, M.; Wang, K.; Wu, W.; Chen. J.; Yang, Z. “An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels-Alder/Retro-Diels-Alder Cascade Reactions” Org. Lett. 2007, 9, 805.
Che, C.; Xiang, J.; Wang, G. X.; Quan, J.-M.; Yang, Z. “A One-Pot Synthesis of Quinoline-based Tetracycles by a Tandem Three-Component Reaction” J. Comb. Chem. (in print)
Liang, B.; Liu, J.; Gao, Y.-X.; Shu, D.-X.; Wongkhan, K.; Lan, Y.; Li, A.; Batsanov, A. S.; Howard, J. A. H.; Marder, T. B.; Chen, J.-H.; Yang, Z. “Synthesis of Thiourea-Oxazolines, a New Class of Chiral S,N-Heterobidentate Ligands: Application in Pd-Catalyzed Asymmetric Bis-methoxycarbonylation of Terminal Olefins” Organometallics (in print).
Deng, L.-J.; Liu, J.; Huang, J.-Q.; Hu, Y.; Chen, M.; Lan, Y.; Chen, J.-H.; Lei, A.; Yang, Z. “Effect of LiCl on Tuning the Reactivity of Pd-TMTU Catalyzed Pauson-Khand Reactions” Synthesis 2007 (in print)

Patent:

Nicolaou, K. C.; Sarabia, F.; Ninkovic, S.; Yang, Z.; He, H.; Vourloumis, D.; Vallberg, H. “Synthetic Approaches for Epothilone A and Related Analogs” U.S. Patent, Serial No. 08/856,533.
Nicolaou, K. C.; He, Y.; Ninkovic, S.; Pastor, J.; Roschangar, F.; Sarabia, F.; Vallberg, H.; Vourloumis, D.; Winssinger, N.; Yang, Z.; King, N.P. “Epothilone Analogs” U.S. Patent, Serial No. 08/923,869.
Nicolaou, K.C. Sorenson, E.J.; Nakada, M.; Yang, Z. “Strutagy for ABC taxoid ring synthesis.” U.S. Patent, Serial No. 08/197,637.
Nicolaou, K. C.; Yang, Z.; Liu, J. J.; Ueno, H.; Nantermet, P. G. “Total synthesis of taxol and taxol analogs” U.S., 15 pp. Cont.-in-part of U.S. Ser. No. 193,263. CODEN: USXXAM. US 5461169 A 951024. CAN 124:87427 CAPLUS.
Yang, Z.; Kobori, M.; Yuan, J.-Y. “Methods for Treating Cell Death Disease and Inflammation” Internationl patent No. PCT/US00/42808, and US 6,552,071 B2
Liao, Y.; Fathi, R.; Yang, Z. “Benzo[b]furan’s Dimers” Patent No.: US 6,855,822 B 2.

Book Chapters

Xue-Long Hou, Zhen Yang and Henry N. C. Wong, “Five-Membered Rings Systems: Furans and Benzofurans”, Progress in Heterocyclic Chemistry, Vol. 13, Amsterdam, pp. 130-166 (2001)
Xue-Long Hou, Zhen Yang and Henry N. C. Wong, “Five-Membered Rings Systems: Furans and Benzofurans”, Progress in Heterocyclic Chemistry, Vol. 14, Amsterdam, pp. 139-179 (2002)
Xue-Long Hou, Zhen Yang and Henry N. C. Wong, “Five-Membered Rings Systems: Furans and Benzofurans”, Progress in Heterocyclic Chemistry, Vol. 15, Amsterdam, pp. 167-205(2003)
Xue-Long Hou, Zhen Yang, and Henry N. C. Wong, “Five-Membered Rings Systems: Furans and Benzofurans”, Progress in Heterocyclic Chemistry, Vol. 16, Amsterdam, 245-327 (2004).
Xue-Long Hou, Zhen Yang, Kap-Sun Yeung and Henry N. C. Wong, “Five-Membered Rings Systems: Furans and Benzofurans”, Progress in Heterocyclic Chemistry, Vol. 16, Amsterdam, 2005 (in print).