Academic Education and Professional Experience:
2016.07-Now Principle Investigator, College of Chemistry and Molecular Engineering, Peking University
2016.07-Now Principle Investigator, PKU-Tsinghua Centre for Life Sciences
2014.09-2016.07 Postdoctoral Research Fellow, National Institutes of Health
2010.09-2014.09 Ph.D. Department of Chemistry, University of British Columbia
2012.05-2014.09 Ph.D. Co-op Program, BC Cancer Agency
2011.05-2014.09 Ph.D. Co-op Program, TRIUMF National Laboratory
2006.09-2010.06 B.S. Department of Chemistry, Nanjing University
Honor:
- 2019.12, 药明康德生命化学青年学者奖
- 2019.12, 北京大学青年教师教学基本功大赛一等奖
- 2018.11, Fairchild Award, 18th International Congress of Neutron Capture Therapy
- 2018.11, 北京大学绿叶生物青年科学家奖
- 2015.06, JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging
- 2015.04, Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging
- 2014.08, Edward Piers Memorial Award, Edward Piers Foundation
- 2014.06, Chinese Government Award for Outstanding Abroad Students, China Scholarship Council
- 2013.06, Young Investigator Award, 37th CASNMMI
- 2013.02, Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation
Research Interests:
Research in the Liu group focuses on the development of novel radioactive molecules for Positron Emission Tomography (PET). We seek to discover molecular structure and activity that can contribute to interdisciplinary solutions for long-standing challenges in clinics. Our lab works on synthetic organic/bioconjugate chemistry, late-stage radiolabeling, PET imaging and mechanistic studies to persure the molecules of interest in early diagnosis, patient selection and tailored treatment.
Select publications:
- Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426
- Liping Li, Ping Du, Yaxin Shi, Jiyuan Li, Zizhu Zhang, Tong Liu, Ruiping Zhang*, Zhibo Liu*, On-demand Biodegradable Boron Nitride Nanoparticles for Positron Emission Tomography Guided Boron Neutron Capture Therapy. ACS Nano, 2019, 13 (12), 13843-13852
- Jiyuan Li, Yaxin Shi, Zizhu Zhang, Hui Liu, Lixin Lang, Tong Liu, Xiaoyuan Chen*, Zhibo Liu*, A Metabolically Stable Boron-Derived Tyrosine Serves as a Theranostic Agent for Positron Emission Tomography Guided Boron Neutron Capture Therapy. Bioconjugate Chem, 2019, 30 (11), 2870-2878
- Dongban Duan, Hui Liu, Mengxin Xu, Mengqi Chen, Yuxiang Han, Yaxin Shi, Zhibo Liu* Size-Controlled Synthesis of Drug Loaded Zeolitic Imidazolate Framework in Aqueous Solution and Size Impact on Their Cancer Theranostics In Vivo. ACS Appl. Mater. Interfaces., 2018, 10 (49), 42165-42174
- Yaxin Shi, Jiyuan Li, Zizhu Zhang, Dongban Duan, Zhengchu Zhang, Hui Liu, Tong Liu, Zhibo Liu* Tracing Boron with Fluorescence and PET Imaging of Boronated Porphyrin Nanocomplex for Imaging Guided Boron Neutron Capture Therapy. ACS Appl. Mater. Interfaces., 2018, 10 (50), 43387-43395
- Mengxin Xu, Yuxiang Han, Guizhong Liu, Yang Xu, Dongban Duan, Hui Liu, Felix Du, Peter Luo, Zhibo Liu* Preclinical Study of A Fully Human Anti-PD-L1 Antibody as A Theranostic Agent for Cancer Immunotherapy. Mol Pharm. 2018, 15(10): 4426-4433.
- Dongban Duan, Hui Liu, Yang Xu, Yuxiang Han, Mengxin Xu, Zhengchu Zhang, Zhibo Liu*. Activating TiO2 Nanoparticle: Gallium-68 Serves As A High-Yielded Photon Emitter for Cerenkov Induced Photodynamic Therapy. ACS Appl. Mater. Interfaces. 2018, 10 (6), 5278–5286
- Zhibo Liu*, Xiaoyuan Chen* Simple Bioconjugate Chemistry Serves Great Clinical Advances: Albumin as A Versatile Platform for Diagnosis and Precision Therapy. Chem. Soc. Rev., 2016, 45, 1432-1456
- Zhibo Liu*, Haojun Chen, Kai Chen, Yihan Shao, Dale O. Kiesewetter, Gang Niu, Xiaoyuan Chen* Boramino Acid as A Marker for Amino Acid Transporter. Sci. Adv., 2015;1:e1500694 (co-corresponding author, highlighted on C&EN News)
- Zhibo Liu*, Kuo-Shyan Lin, François Bénard, Dale O. Kiesewetter, David M. Perrin*, Xiaoyuan Chen* A Broadly Applicable One-step 18F-Labeling Protocol with Organotrifluoroborates. Nat. Protoc, 2015, 10, 1423–1432 (co-corresponding author)
- Zhibo Liu, Maral Pourghiasian, Gemma Dias, Joseph Lau, Francois Benard, Kuo-shyan Lin, David M. Perrin, An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling, Angew. Chem. Int. Ed., 2014, 53, 11876–11880 (Cover feature, highlighted on C&EN News)
- Zhibo Liu, Ying Li, Jerome Lozada, Paul Schaffer, Michael J. Adam, Thomas J. Ruth, David M. Perrin, Stoichiometric Leverage: Rapid 18F-Aryltrifluoroborate Radiosynthesis at Exceptionally High Specific Activity For Click Conjugation, Angew. Chem. Int. Ed., 2013, 52, 2303-2307
