Research Experience
2022-now: Executive Editor, ACS Chemical Biology, American Chemical Society
2020-now: Director, Synthetic and Functional Biomolecules Center, Peking University
2021-now: Director, Division of Chemical Biology, Chinese Chemical Society
2015-now: Chairman, Department of Chemical Biology, Peking University
2014-now: Professor, Department of Chemical Biology, Peking University
2011-2015: Investigator, Peking-Tsinghua Center for Life Sciences
2009-2014: Investigator, Department of Chemical Biology, College of Chemistry, Peking University
2007-2009: Postdoctoral Fellow, the Scripps Research Institute, Advisor: Prof. Peter G. Schultz
2002-2007: Ph.D in Chemistry (2007), University of Chicago, Chicago, USA
1998-2002: B.S. in Chemistry, Peking University, Beijing, China
1999-2002: B.S. Double degree in Economics, Peking, Beijing, China
Research Interests
Our group is interested in developing and applying new chemistry tools to investigate protein-based interactions and activities in living systems. We have been leading the development of bioorthogonal cleavage reactions, which has enabled the in situ gain-of-function study of proteins as well as other biomolecules in living cells and animals. This has opened an exciting new avenue in bioorthogonal chemistry with broad utilities in life sciences and medicine. We have also developed a series of genetically encoded protein labeling, crosslinking and proximity-tagging tools for monitoring biomolecule interactions as well as cell communications during various physiological and pathological processes. Most recently, we started to leverage this exciting toolkit to better understand the mode-of-action of immunotherapy.
Awards
2023: The Science and Technology Innovation Award, Ho Leung Ho Lee Foundation
2023: New Cornerstone Investigator
2020: National Award for Natural Sciences of China
2010: Fellow, Chinese Chemical Society
2019: Natural Science Award, Ministry of Education, China
2019: XPLORER Prize
2019: C.C. Tan Life Science Award
2017: Society of Biological Inorganic Chemistry (SBIC) Early Career Award
2016: Tan Kah Kee Young Scientist Award
2016: Young Scientist Award, Ministry of Education (China)
2016: OKeanos-CAPA Young Investigator Award at the Chemistry and Biology Interface
2015: China Association for Instrumental Analysis (CAIA) Award
2015: The Chemical Society of Japan Distinguished Lectureship Award
2015: Young Science and Technology Innovation Talents
2014: Roche Chinese Young Investigator Award
2014: (RSC) Chem Soc Rev Emerging Investigator Lectureship
2014: CAPA Biomatik Distinguished Faculty Award
Selected Publications
- Li K, Xie X, Gao R, et al, Chen P. “Spatial-temporal protein interactome profiling via condensation enhanced photo-crosslinking”, Nat. Chem. (2024), accepted.
- Zhu Y, Ding W, Fan X, Lin S, Chen P, “Genetically encoded bioorthogonal tryptophan decaging in living cells”, Nat. Chem. (2024), 16, 533-42.
- Weng Y, Chen W, Kong Q, et al, Tian R, Chen P. “DeKinomics pulse-chases kinase functions in living cells”, Nat. Chem. Biol. (2024), 20, 615-23.
- Qin F, Li B, Wang H, Ma S, et al, Ji X, Chen P. “Linking chromatin acylation mark-defined proteome and genome in living cells”, Cell, (2023), 186, 1066-85.
- Huang Z, Liu Z, Xie X, Zeng R, Chen Z, Kong L, Fan X, Chen P. “Bioorthogonal photocatalytic decaging-enabled mitochondrial proteomics”, J. Am. Chem. Soc. (2021), 143, 18714-20.
- Liu Y, Zeng R, Zou P, Chen P. “Spatiotemporally resolved subcellular phosphoproteomics”, Proc. Natl. Acad. Sci. USA. (2021), 118, e2025299118.
- Wang J, Liu Y, Liu YJ, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C, Chen P. “Time-resolved protein activation by proximal decaging in living systems”, Nature, (2019), 569, 509-13.
- Li J, Chen P. “Development and application of bond cleavage reactions in bioorthogonal chemistry”, Nat. Chem. Biol. (2016), 12, 129-37.
- Li J, Jia S, Chen P. “Diels-Alder reaction-triggered bioorthogonal protein activation in living cells”, Nat. Chem. Biol. (2014), 10, 1003-5.
- Li J, Yu J, et al, Chen P. “Palladium-triggered deprotection chemistry for protein activation in living cells”, Nat. Chem. (2014), 6, 352-61.
