publications
2024
62.Mengyan Bai#, Wenxin Lin#, Chunyan Peng#, Peizhe Song#, Huaqin Kuang, Jieni Lin, Jieping Zhang, Jiyao Wang, Bo Chen, Huarong Li, Fanjiang Kong, Guifang Jia*, Yuefeng Guan*. Expressing a human RNA demethylase as an assister improves gene-editing efficiency in plants. Molecular Plant, 2024, 17, 363-366.
61.Hong-Chao Duan#, Chi Zhang#, Peizhe Song, Junbo Yang, Ye Wang, Guifang Jia*. C2-methyladenosine in tRNA promotes protein translation by facilitating the decoding of tandem m2A-tRNA-dependent codons. Nature Communications, 2024, 15(1), 1025.
60.Lin Zhang#, Hong-Chao Duan#, Marcin Paduch#, Jingyan Hu, Chi Zhang, Yajuan Mu, Houwen Lin, Chuan He, Anthony A. Kossiakoff, Guifang Jia*, Liang Zhang*. The molecular basis of human ALKBH3 mediated RNA N1-methyladenosine (m1A) demethylation. Angewandte Chemie International Edition, 2024, 63(7), e202313900.
2023
59.Peizhe Song#, Lianhuan Wei#, Zixin Chen#, Zhihe Cai, Qiang Lu, Chunling Wang, Enlin Tian, Guifang Jia*. m6A readers ECT2/ECT3/ECT4 enhance mRNA stability through direct recruitment of the poly(A) binding proteins in Arabidopsis. Genome Biology, 2023, 4(1):103.
58.Jun Tang, Shuyan Chen, Guifang Jia*. Detection, regulation, and functions of RNA N6-methyladenosine modification in plants. Plant Communication, 2023, 4(3): 100546.
57.Yuxin Zhang#, Jie Jiang#, Jiongming Ma#, Zhen Wei*, Yue Wang, Bowen Song, Jia Meng, Guifang Jia, João Pedro de Magalhães, Daniel J Rigden, Daiyun Hang*, Kunqi Chen*. DirectRMDB: a database of post-transcriptional RNA modifications unveiled from direct RNA sequencing technology. Nucleic Acids Research, 2023, 51(D1): D106-D116.
2022
56.Bin Sun#, Kaushal Kumar Bhati#, Peizhe Song#, Ashleigh Edwards, Louise Petri, Valdeko Kruusvee, Anko Blaakmeer, Ulla Dolde, Vandasue Rodrigues, Daniel Straub, Junbo Yang, Guifang Jia*, Stephan Wenkel*. FIONA1-mediated methylation of the 3'UTR of FLC affects FLC transcript levels and flowering in Arabidopsis. PLoS Genet. 2022, 18(9):e1010386.
55.Jun Tang#, Junbo Yang#, Qiang Lu, Qian Tang, Shuyan Chen, Guifang Jia*. The RNA N6-methyladenosine demethylase ALKBH9B modulates ABA responses in Arabidopsis. J. Integr. Plant Biol. 00: 1-14
54. Yuxin Zhang#, Jie Jiang#, Jiongming Ma#, Zhen Wei*, Yue Wang, Bowen Song, Jia Meng, Guifang Jia, João Pedro de Magalhães, Daniel J Rigden, Daiyun Hang*, Kunqi Chen*. DirectRMDB: a database of post-transcriptional RNA modifications unveiled from direct RNA sequencing technology. Nucleic Acids Research, 2022, gkac1061.
53.Chunling Wang#, Junbo Yang#, Peizhe Song, Wei zhang, Qiang Lu, Qiong Yu, Guifang Jia*. FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorpho-genesis and flowering. Genome Biol. 2022 Jan 31;23(1):40. doi: 10.1186/s13059-022-02612-2.
2021
52.Qiong Yu#, Shun Liu#, Lu Yu, Yu Xiao, Shasha Zhang, Xueping Wang, Yingying Xu, Hong Yu, Yulong Li, Junbo Yang, Jun Tang, Hong-Chao Duan, Lian-Huan Wei, Haiyan Zhang, Jiangbo Wei, Qian Tang, Chunling Wang, Wutong Zhang, Ye Wang, Peizhe Song, Qiang Lu, Wei Zhang, Shunqing Dong, Baoan Song*, Chuan He*, Guifang Jia*. RNA demethylation increases the yield and biomass of rice and potato plants in the field trials. Nature Biotechnology, 2021, doi: 10.1038/s41587-021-00982-9.
51.Congyao Xu#, Zhe Wu#, Hong-Chao Duan#, Xiaofeng Fang, Guifang Jia*, Caroline Dean*. R-loop resolution promotes co-transcriptional chromatin silencing. Nature Communications, 2021, 12, 1790.
50.Peizhe Song#, Junbo Yang#, Chunling Wang, Qiang Lu, Linqing Shi, Subiding Tayier, Guifang Jia*. Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signal to control polyadenylation site choice in liquid-like nuclear body. Molecular Plant, 2021, 14, 571-587.
49.Miao Wang#, Yu Xiao#, Yan Li#, Xiaoying Wang, Suzhen Qi, Ye Wang, Liuwei Zhao, Kai Wang, Wenjun Peng, Guan-Zheng Luo*, Xiaofeng Xue*, Guifang Jia*, Liming Wu*. RNA m6A modification functions in larval development and caste differentiation in honeybee (Apis mellifera). Cell Report, 2021, 34(1)108580.
48.Wei Zhang, Qian Yang, Guifang Jia*. The detection and functions of RNA modification m6A based on m6A writers and erasers. Journal of Chemical Biology, 2021, 297, 100973.
47.Tang J, Yang J, Duan H and Guifang Jia*. ALKBH10B, an mRNA m6A Demethylase, Modulates ABA Response During Seed Germination in Arabidopsis. Front. Plant Sci. 12:712713. doi: 10.3389/fpls.2021.712713.
2020
46.Ye Wang, Guifang Jia*. Detection methods of epitranscriptomic mark N6-methyladenosine. Essays in Biochemistry, 2020, 64, 967-979.
45.Ye Wang, Yu Xiao, Shunqing Dong, Qiong Yu, Guifang Jia*. Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine. Nature Chemical Biology, 2020, 16, 896-903.
44.Haiping Song, Ye Wang, Ruixiang Wang, Xiao Zhang, Yaping Liu, Guifang Jia*, Peng R.Chen*. SFPQ is an FTO-binding protein that facilitates the demethylation substrate preference. Cell Chemical Biology, 2020, 27, 283-291.
43.Jin-Hong Luo, Ye Wang, Min Wang, Li-Yuan Zhang, Hui-Ru Peng, Yu-Yi Zhou, Guifang Jia, Yan He*. Natural variation in RNA m6A methylation and its correlation with translational status in maize. Plant Physiology, 2020, 182, 332-344.
42.Qian Tang, Wutong Zhang, Guifang Jia*. Advances in biological functions of RNA chemical modification m6A. Sci Sin Chim, 2020, 50: 1233–1249.
2019
41.Xiao Zhang, Lian-Huan Wei, Yuxin Wang, Yu Xiao, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang*, Guifang Jia*. Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proceedings of National Academy of Sciences of the United States of America, 2019, 116, 2919.
40.Hong-Chao Duan, Ye Wang, Guifang Jia*. Dynamic and reversible RNA N6-methyladenosine methylation. Wiley Interdiscip Review RNA, 2019, 10, e1507.
39.Chengchuan Ma, Rong Niu, Tianxiao Huang, Li-Wa Shao, Yong Peng, Wanqiu Ding, Ye Wang, Guifang Jia, Chuan He, Chuan-Yun Li, Aibin He, Ying Liu. N6-methyldeoxyadenine is a trans-generational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology, 2019, 21, 319.
2018
38.Yu Xiao, Ye Wang, Qian Tang, Lianhuan Wei, Xiao Zhang, Guifang Jia*. An elongation and ligation-based qPCR amplification method for the radiolabeling-free detection of locus-specific N6-methyladenosine modification. Angewandte Chemie International Edition, 2018, 57, 15995.
37.Lian-Huan Wei, Peizhe Song, Ye Wang, Zhike Lu, Qian Tang, Qiong Yu, Yu Xiao, Xiao Zhang, Hong-Chao Duan, Guifang Jia*. The m6A reader ECT2 controls trichome morphology by affecting mRNA stability in Arabidopsis, Plant Cell, 2018, 30, 968-985.
36.Zhang Chi, Guifang Jia*. Reversible RNA modification N1-Nmethyladenosine (m1A) in mRNA and tRNA. Genomics Proteomics Bioinformatics. 2018, 16, 155-161.
35.Jiangbo Wei, Fange Liu, Zhike Lu, Qili Fei, Yuxi Ai, P. Cody He, Hailing Shi, Xiaolong Cui, Rui Su, Arne Klungland, Guifang Jia, Jianjun Chen, Chuan He. Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm. Molecular Cell, 2018, 71, 973.
34.Johnny Truong, Yu-Fang Hsieh, Lynda Truong, Guifang Jia, Ming C. Hammond. Designing fluorescent biosensors using circular permutations of riboswitches. Methods, 2018, 143, 102.
33.Hong-Chao Duan, Lian-Huan Wei, Chi Zhang, Ye Wang, Lin Chen, Zhike Lu, Peng Chen, Chuan He*, Guifang Jia*. ALKBH10B is an RNA N6-methyladenosine demethylase affecting Arabidopsis floral transition, Plant Cell, 2017, 29, 2995.
32.Lian-Huan Wei, Guifang Jia*. Epitranscriptomic modification-N6-methyldenosine (m6A) and plant development. University Chemistry, 2017, 32, 1-10.
31.Zhen Lin, Phillip J Hsu, Xudong Xing, Jianhuo Fang, Zhike Lu, Qin Zou, Ke-Jia Zhang, Xiao Zhang, Yuchuan Zhou, Teng Zhang, Youcheng Zhang, Wanlu Song, Guifang Jia, Xuerui Yang, Chuan He, Ming-Han Tong. Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis. Cell Research, 2017, 27, 1216.
30.Wenshuai Li, Xu Zhang, Xingyu Lu, Lei You, Yanqun Song, Zhongguang Luo, Jun Zhang, Ji Nie, Wanwei Zheng, Diannan Xu, Yaping Wang, Yuanqiang Dong, Shulin Yu, Jun Hong, Jianping Shi, Hankun Hao, Fen Luo, Luchun Hua, Peng Wang, Xiaoping Qian, Fang Yuan, Lianhuan Wei, Ming Cui, Taiping Zhang, Quan Liao, Menghua Dai, Ziwen Liu, Ge Chen, Katherine Meckel, Sarbani Adhikari, Guifang Jia, Marc B Bissonnette, Xinxiang Zhang, Yupei Zhao, Wei Zhang, Chuan He, Jie Liu. 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers. Cell Research, 2017, 27, 1243.
2016
29.Wang Ye, Guifang Jia*. New edges of RNA adenosine methylation modifications. Genomics Proteomics Bioinformatics, 2016, 14, 172.
28. Xiao Zhang, Guifang Jia*. RNA epigenetic modification: N6-methyladenosine. Hereditas (Beijing), 2016, 38, 275-288.
2015
27. Yue Huang#, Jingli Yan#, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Guifang Jia*, Cheng Luo*, Cai-Guang Yang*. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5, Nucleic Acids Research, 2015, 43, 373.
2014
26.Guan-Zheng Luo#, Alice MacQueen#, Guanqun Zheng#, Hongchao Duan, Louis C. Dore, Zhike Lu, Jun Liu, Kai Chen, Guifang Jia*, Joy Beigelson*, Chuan He*, Unique features of the m6A methylome in Arabidopsis thaliana, Nature Communications, 2014, 5, 5630.
25.Liu Jun, Guifang Jia*. Methylation modifications in eukaryotic messenger RNA, Journal of Genetic Genomics, 2014, 41, 21.
24.Xu Zhao, Ying Yang, Bao-Fa Sun, Yue Shi, Xin Yang, Wen Xiao, Ya-Juan Hao, Xiao-Li Ping, Yu-Sheng Chen, Wen-Jia Wang, Kang-Xuan Jin, Xing Wang, Chun-Min Huang, Yu Fu, Xiao-Meng Ge, Shu-Hui Song, Hyun Seok Jeong, Hiroyuki Yanagisawa, Yamei Niu, Guifang Jia, Wei Wu, Wei-Min Tong, Akimitsu Okamoto, Chuan He, Jannie M Rendtlew Danielsen, Xiu-Jie Wang, Yun-Gui Yang. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Research, 2014, 24, 1403.
Other Publications
23.Jianzhao Liu, Yanan Yue, Dali Han, Xiao Wang, Ye Fu, Liang Zhang, Guifang Jia, Miao Yu, Zhike Lu, Xin Deng, Qing Dai, Weizhong Chen, Chuan He. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nature Chemical Biology, 2014, 10, 93.
22.Xiao Wang, Zhike Lu, Adrian Gomez, Gary C. Hon, Yanan Yue, Dali Han, Ye Fu, Marc Parisien, Qing Dai, Guifang Jia, Bing Ren, Tao Pan, Chuan He. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature, 2014, 505, 117.
21.Guanqun Zheng, John A Dahl, Yamei Niu, Peter Fedorcsak, Chun-Min Huang, Charles J. Li, Cathrine B. Vågbø, Shi Yue, Wen-Ling Wang, Shu-Hui Song, Zhike Lu, Ralph P.G. Dosmans, Qing Dai, Ya-Juan Hao, Xin Yang, Wen-Ming Zhao, Wen-Min Tong, Xiu-Jie Wang, Florian Bogdan, Kari Furu, Ye Fu, Guifang Jia, Xu Zhao, Jun Liu, Hans E. Krokan, Arne Klungland, Yun-Gui Yang, Chuan He. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Molecular Cell, 2013, 49, 18.
20.Ye Fu#, Guifang Jia#, Xueqin Pang, Richard N. Wang, Xiao Wang, Charles J. Li, Scott Smemo, Qing Dai, Kathleen A. Bailey, Marcelo A. Nobrega, Ke-Li Han, Qiang Cui, Chuan He. FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA, Nature Communications, 2013, 4, 1798.
19.Guifang Jia, Ye Fu, Chuan He. Reversible RNA adenosine methylation in biological regulation, Trends in Genetics, 2013, 29, 108.
18.Baoen Chen, Fei Ye, Lu Yu, Guifang Jia, Xiaotian Huang, Xueju Zhang, Shuying Peng, Kai Chen, Meining Wang, Shouze Gong, Ruihan Zhang, Jinya Yin, Haiyan Li, Yiming Yang, Hong Liu, Jiwen Zhang, Haiyan Zhang, Ao Zhang, Hualiang Jiang, Cheng Luo, Cai-Guang Yang. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor, Journal of the American Chemical Society, 2012, 134, 17963.
17.Chengqi Yi, Baoen Chen, Bo Qi, Wen Zhang, Guifang Jia, Liang Zhang, Charles Q. Li, Aaron Dinner, Cai-Guang Yang, Chuan He. Duplex DNA Interrogation by a Direct DNA Repair Protein, Nature Structure & Molecular Biology, 2012, 19, 671.
16.Guifang Jia#, Ye Fu#, Xu Zhao#, Qing Dai, Guanqun Zheng, Ying Yang, Chengqi Yi, Tomas Lindahl, Tao Pan, Yun-Gui Yang, Chuan He*. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO, Nature Chemical Biology, 2011, 7, 885.
15.Chengqi Yi, Guifang Jia, Guanhua Hou, Qing Dai, Wen Zhang, Guanqun Zheng, Xing Jian, Cai-Guang Yang, Qiang Cui, Chuan He. Iron-Catalyzed Oxidation Intermediates Captured in a DNA Repair Dioxygenase, Nature, 2010, 468, 330.
14.Guifang Jia#, Cai-Guang Yang#, Shangdong Yang, Xing Jian, Chengqi Yi, Chuan He. Oxidative demethylation of 3-meT and 3-meU in single-stranded DNA and RNA by mouse and human FTO, FEBS Letters, 2008, 582, 3313.
13.Guifang Jia, Chunguang Lv, Wentao Zhu, Jing Qiu, Xinquan Wang, ,Zhiqiang Zhou. Applicability of cloud point extraction coupled with microwave assisted back-extraction to the determination of organophosphorous pesticides in human urine by gas chromatography with flame photometry detection, Journal of Hazard Material, 2008, 159, 300.
12.Guifang Jia, Li Li, Jing Qiu, Xinquan Wang, Wentao Zhu, Ying Sun, Zhiqiang Zhou. Determination of carbaryl and its metabolite 1-naphthol in water samples by fluorescence spectrophotometer after anionic surfactant micelle-mediated extraction with sodium dodecylsulfate, Spectrochim Acta Part A, 2007, 67, 460.
11.Chunguang Lv, Guifang Jia, Wentao Zhu, Jing Qiu, Xinquan Wang, Zhiqiang Zhou. Enantiomeric resolution of new triazole compounds by high perform liquid chromatography, Journal of Separation Science, 2007, 30, 344.
10.Xinquan Wang, Guifang Jia, Jing Qiu, Jinling Diao, Wentao Zhu, Chunguang Lv, Zhiqiang Zhou. Stereoselective degradation of fungicide Benalaxyl in soils and Cucumber plants, Chirality, 2007, 19, 300.
9. Jing Qiu, Qiuxia Wang, Wentao Zhu, Guifang Jia, Xinquan Wang, Zhiqiang Zhou. Stereoselective determination of benalaxyl in plasma by chiral high-performance liquid chromatography with diode array detector and application to pharmacokinetic study in rabbits, Chirality, 2007, 19, 51.
8. Wentao Zhu, Jing Qiu, Ziheng Dang, Chunguang Lv, Guifang Jia, Li Li, Zhiqiang Zhou. Stereoselective degradation kinetics of tebuconazole in rabbits, Chirality, 2007, 19, 141.
7. Wentao Zhu, Ziheng Dang, Jing Qiu, Chunguang Lv, Guifang Jia, Li Li, Zhiqiang Zhou. Stereoselective toxicokinetics and tissue distribution of ethofumesate in rabbits, Chirality, 2007, 19, 632.
6. Guifang Jia, Chenglu Bi, Qiuxia Wang, Jing Qiu, Wentao Zhu, Zhiqiang Zhou. Determination of etofenprox in environmental samples by HPLC after anionic surfactant micelle-mediated extraction (coacervation extraction), Analytical & Bioanalytical Chemistry, 2006, 384, 1423.
5. Qiuxia Wang, Jing Qiu, Wentao Zhu, Guifang Jia, Junling Li, Chenglu Bi, Zhiqiang Zhou. Stereoselective degradation kinetics of theta-cypermethrin in rats, Environment Science &Technology, 2006, 40, 721.
4. Jing Qiu, Qiuxia Wang, Ping Wang, Guifang Jia, Junling Li, Zhiqiang Zhou. Enantioselective degradation kinetics of metalaxyl in rabbits, Pesticide Biochemistry and Physiology, 2005, 83, 1.
3. Qiuxia Wang, Jing Qiu, Ping Wang, Guifang Jia, Peng Wang, Junling Li, Zhiqiang Zhou. Stereoselective kinetic study of hexaconazole enantiomers in the rabbit, Chirality, 2005, 17, 186.
2. Guifang Jia，Peng Wang，Jing Qiu，Ying Sun，Yumei Xiao, Zhiqiang Zhou. Determination of DNA with imidacloprid by a resonance light scattering technique at nanogram levels and its application，Analytical Letters, 2004, 37, 1339.
1. Nianqin Jie*, Guifang Jia, Shicong Hou, Yanmei Xiong, Yanhong Dong. Determination of deoxyribonucleic acids by a resonance light scattering technique and its application, Spectrochim Acta Part A, 2003, 59, 3295.