Wei-Ting’s work on dioxygen-promoted cobalt-catalyzed Oxidative Hydroamination Using Unactivated Alkenes and Free Amines has been published on Chem. Catal..
This work address the challenge of catalytic Markovnikov-selective hydroamination of unactivated alkenes using secondary amines nucleophiles and/or in an intermolecular setting by developing a cobalt hydride-catalyzed hydroamination reaction based on a bimetallic redox-triggered oxidative amination pathway. This system enables the use of dioxygen as a sustainable oxidant that is compatible with free amines, while suppresses the facile radical oxygenation that leads to the classical Drago-Mukaiyama oxidation.
